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The Main Factor That Causes The Ampoules To Deteriorate
Aug 09, 2017

The main factor that causes the Ampoules to deteriorate
The air containing 1/5 of oxygen, oxygen chemical properties are very lively, can make a number of reductive drugs oxidation, deterioration or even produce toxicity, such as oil oxidation after the rancidity; "914" ; Carbon dioxide in the air can make some drugs "carbonated", such as sulfa drugs sodium salt, barbiturate drugs; bleaching powder in the presence of moisture conditions, can absorb carbon dioxide, slowly release chlorine and make it Ineffective.
Daylight can make many Ampoules directly or promote their chemical changes (oxidation, reduction, decomposition, polymerization, etc.) and deterioration, which is mainly the role of ultraviolet light, such as adrenaline light can be affected by the red; silver salt and mercury salt see light Was reduced and precipitated free silver and mercury, the color becomes darker, the toxicity increases.
The increase in temperature not only accelerates the volatilization of Ampoules, but also promotes chemical reactions such as oxidation and decomposition to accelerate the deterioration of Ampoules, such as serum, vaccines, and organ preparations, which are easy to be stored at room temperature and require low temperature refrigeration; But also easy to soften the ointment, capsules softening, so that volatile drugs to accelerate the speed, but the temperature is too low will make some Ampoules or preparation precipitation, such as formaldehyde in 90 ℃ below the formation of polymer formaldehyde precipitation precipitation; low temperature also easy to liquid The drug is frozen and the container is broken.
The moisture content in the air is called the humidity. The humidity is the most volatile part of the air, fluctuating with the area, season, and temperature. The humidity has a great influence on the Ampoules storage. The humidity is too large to make the Ampoules absorb moisture and deliquescence , Dilution, deformation, moldy; humidity is too small, easy to make water containing Ampoules.
Microbes and insects
Ampoules exposed in the air, due to microbial and insect invasion, leaving the Ampoules corruption, fermentation, mildew and insects.
Any Ampoules storage time is too long, will be bad, but different Ampoules changes in the speed of different antibiotics, biological products, organ preparations and some chemical Ampoules are provided for the validity period, must be used within the validity period.
[General method of Ampoules storage]
Closed is the container sealed, to prevent dust and foreign matter mixed, such as glass bottles, paper bags and so on.
Seal is to seal the container to prevent weathering, moisture absorption, volatile or foreign matter pollution, such as with a tight glass plug or cork glass bottles, ointment and so on.
Sealing or sealing means that the container is sealed or sealed in a suitable standard to prevent air, moisture ingress and bacterial contamination, such as glass Ampoules.
Shading containers are brown containers or colorless glass containers wrapped in black paper and other suitable containers.
The provisions of the temperature of the shade, is not more than 20 ℃; cool dark, refers to the light and not more than 20 ℃; cold, refers to 2 ℃ ~ 10 ℃.
The provisions of the humidity dry place, refers to the relative humidity of 75% or less in the ventilation, dry place
According to the nature of Ampoules, dosage forms, combined with the specific circumstances of the pharmacy, take the "classification classification, location number" approach to safe custody. (Such as strong oxidants and reducing agents, acids and salts), and the use of drugs such as strong oxidizing agents, Alkali) and the name of the drug should be confused should be stored separately. The establishment of Ampoules custody account, regular inspection, regular inventory, to ensure that accounts and Ampoules match. The ampule should always be kept clean and take effective measures to prevent mildew, insects and rodents. Strengthen fire safety and other safety measures to ensure the safety of personnel and Ampoules.